Professor Carlos Correia’s main research interest include the development of new synthetic methodologies involving palladium, enantioselective catalysis, and organic synthesis aiming at the synthesis of natural products, bioactive heterocyclic compounds, pharmaceuticals and functional compounds in a concise and practical manner.
- Daniela A. Barancelli, Airton G. Salles Jr., Jason G. Taylor and Carlos Roque D. Correia, “Coumarins from Free ortho-Hydroxy Cinnamates by Heck-Matsuda Arylations: A Scalable Total Synthesis of (R)-Tolterodine”, Org. Lett. 2012, 14, 6036-6039. http://dx.doi.org/10.1021/ol302923f
- Cristiane S. Schwalm and Carlos Roque D. Correia "Divergent total synthesis of the natural antimalarial marinoquinolines A, B, C, E and unnatural analogues" Tetrahedron Lett. 2012, 53, 4836-4840. http://dx.doi.org/10.1016/j.tetlet.2012.06.115
The Heck-Matsuda is one of our major interests.
Home made video of a Heck-Matsuda reaction carried out at 1 mol scale by an undergraduate student
Arenediazonium tetrafluoroborates are extremely easy-handle substrates. They have scalable synthesis, can be isolated and stored up to several months without risk. Their reactivity towards palladium catalysis improves the opportunities for efficient and mild arylation methods
A crystalline sample of 4-methoxyphenyl diazonium tetrafluoroborate